Your Cart

Karden Ingredients

What is Karden?

Karden is a natural health product that provides medium to long-term cardiovascular protection. Its effects are not immediate or drastic, but slow and lasting. Karden, with its main component, Crategus monogyna extract 2.2% flavonoids, is unanimously recognized for its beneficial effects on the heart and circulation in general. Vasodilator, it acts on the coronary artery, which increases the blood supply to the heart muscle, therefore its oxygenation, nutrition and activity. Karden has a diuretic effect, it eliminates fluid retention, thereby lowering hypertension. High blood pressure cannot be cured, but it can be controlled. This means that treatments in this case must bring the numbers back to a normal level of 120/80 and below.

Karden increases the strength of the myocardium, protects the heart, regulates heart rhythm and protects heart muscle cells from possible damage. Karden also reduces nervousness and anxiety.

Diagnosing and treating cardiac disorders require a health professional's intervention due to the risks posed by these diseases. Cardiac disorders often require administering several drugs whose multiple interactions may require sustained medical monitoring. Blood pressure can fluctuate at any time of the day, and medication changes should be made under medical supervision. The MAPA test is very useful for monitoring blood pressure for people with hypertension, i.e. hypertensives.

What is the advantage of Karden and why we formulated Karden?

The treatment of hypertension can include several drugs: "A single pharmacological principle allows the control of only 25% of treated hypertensives," indicates the French Committee for the fight against arterial hypertension in a guide addressed to professionals; in the same publication, it is specified that for 50% of patients, it is necessary “the use of three pharmacological classes in combination to achieve the blood pressure objective."

Why a natural product for high blood pressure?

Each year 1% to 3% of hypertensive patients who receive drug treatment develop diabetes. The risk is higher in those with at least one of the following characteristics: treatment with a diuretic or a beta-blocker, glucose intolerance (fasting or not), obesity (especially abdominal), dyslipidemia, sedentary lifestyle and poor diet.

About 50% of hypertensives under the age of 45 do not take antihypertensives, even if they have multiple cardiovascular risk factors. This is why self-measurement techniques (outside the presence of a doctor) are very useful and essential to define the patients who need to be treated.

How to maximize the therapeutic effect of Karden?

There are two ways to monitor and manage your heart health: medication and lifestyle. Medicines can help control heart disease and high blood pressure but cannot cure them.

A healthy lifestyle can help keep medication use to a minimum. Adopting a healthy lifestyle reduces the risk of high blood pressure and heart disease. This includes practicing regular physical activity, maintaining a healthy weight, managing stress, limiting alcohol consumption and eating a healthy diet, low in sodium, fat and sugars and rich in fruits and vegetables.

What are the main effects of taking the Karden product?

The components of Karden are Crataegus monogyna extract 2.2% flavonoids, magnesium and hibiscus sabdarifa.

Cochrane Database of Systematic Review has published the results of an analysis of ten clinical trials involving 855 patients with heart failure. Patients in the clinical trials suffered from congestive heart failure class I to III.

According to the results, the extract improved exercise capacity (maximum sustained power) and exercise tolerance (endurance). The extract lowered blood pressure and heart rate and improved the heart oxygen consumption index for treated patients. Symptoms of shortness of breath and excessive fatigue were reduced.

Why and when to take Karden?

Karden can be used to treat mild to moderate congestive heart failure (New York Heart Association Class I and II) and reduce anxiety. Taking Karden in addition to conventional medical treatment (diuretics or angiotensin converting enzyme (ACEI) inhibitors) improves resistance to effort. It relieves certain symptoms associated with this disease: high blood pressure, shortness of breath, abnormal at the slightest exertion and fatigue. Karden can be used alone (as monotherapy) in grade I-II blood pressure. It is important to continue self-monitoring of blood pressure (as with all therapies for high blood pressure).

Regarding the main component of Karden, the standardized extract of Caraegus Monogyna, some experts believe that it is an attractive solution for treating the first 2 stages of congestive heart failure, particularly in cases where the patient cannot tolerate synthetic drugs due to certain side effects such as: dry cough, allergies, kidney failure, etc.)

A large trial (2,600 people followed for 2 years) confirmed that hawthorn extract is safe and does not interfere with any medication used in conventional treatment. Hawthorn standardized extracts interact safely and even beneficially with the drugs below, under strict medical supervision.

Digogxin and other digitalis derivatives. In a preliminary crossover trial on 8 healthy people, digoxin was given alone for 10 days, then for 21 days, hawthorn extract was added to this treatment. Hawthorn extract has been found not to influence digoxin metabolism.

Karden Recommended Dosage

It is recommended to take 2 capsules 3 times a day, preferably with meals

The Active Components of Karden

Karden contains two active ingredients: Crataegus monogyna extract, magnesium citrate and a flavour enhancer, hibiscus sabdarifa which has been the subject of several types of research for heart disease, especially for high blood pressure.

Cartaegus Monogyna

Most clinical trials have been carried out on 2 standardized extracts: 18.75% procyanidins and 2.2% flavonoids. This is the reason why we used the flavonoid extract for our formulation.

Over the past 20 years, several clinical studies have been conducted with over a thousand patients with heart failure. They demonstrated that standardized extracts of the leaves of Crataegus mongyna flowers constitute an effective adjuvant treatment for class I and II congestive heart failure according to the classification of the New York Heart Association.


Magnesium is a natural calcium antagonist with the main action of regulating vasomotor tone, blood pressure and peripheral blood circulation.

Its actions as an antihypertensive agent against arrhythmia, anti-inflammatory and anticoagulant make magnesium a beneficial element in preventing and treating cardiovascular diseases.

A systematic review of prospective studies on 313,041 people, of which 11,995 had cardiovascular disease and 10,220 waschemic concluded that higher levels of blood magnesium were associated with a lower risk of cardiovascular disease. Higher dietary magnesium intakes (up to about 250mg/day) have been associated with a significantly lower risk of ischemic heart disease.

A 0.2mmol/L increase in serum magnesium was associated with a 30% lower risk of cardiovascular disease. Magnesium supplementation can have a favourable effect on glucose, HDL-Cholesterol, LDL-Cholesterol, triglycerides and blood pressure levels. Magnesium supplementation may also decrease the risk of diabetes and its impact on cardiovascular disease.

In another clinical trial, magnesium supplementation for 8 to 28 weeks (234-937mg/day) for 545 hypertensive participants showed a 2.2mmHg decrease in diastolic blood pressure. A meta-analysis of 1,173 normal and hypertensive adults concluded that supplementation for 3-24 weeks decreases systolic pressure by 3-4mmHg and diastolic pressure by 2-3mmHg.

“History of use and clinical data undeniably demonstrate the safety of hawthorn and its effectiveness in improving exercise tolerance. On the other hand, in stages (III and IV, according to the scale of the New York Heart Association) the use of hawthorn is not advantageous compared to medication and its effectiveness is questioned. Thus for the elderly suffering from mild heart failure, which a doctor follows, the use of a hawthorn extract is an ideal way to choose the best of both worlds: to treat the disease while avoiding the effects side effects and interactions with other medications. If, over the years, the insufficiency worsens, there will always be time to replace the hawthorn extract with a more powerful drug. But as long as the deficiency is mild, why not take advantage of a completely safe botanical extract? » Jean-Yves Dionne, BScPharm but 2011

Hibiscus Sabdarifa

Hibiscus sabdariffa contains anthocyanins, a subgroup of the flavonoid family recognized for their beneficial effects on cardiovascular health, inhibition of the inflammatory process and on the production of nitric oxide, capture of free radicals, inhibition of xanthine oxidase , chelation of metal ions. Improved LDL-cholesterol oxidation.

Hibiscus sabdariffa has been used as a flavor enhancer, although it is not part of the active ingredients in our formulation, it represents added value for our product. Hibiscus has antioxidant properties, diuretic antihypertensive and increases the excretion of uric acid in the urine.

Recent studies suggest that hibiscus may be effective against metabolic syndrome, particularly in lowering blood sugar, triglycerides, and total cholesterol.

Hibiscus has also been shown in studies to effectively lower blood pressure in pre and moderately hypertensive adults. It is believed that anthocyanins (red-colored flavonoids found in the aqueous extract of this plant) one of the main groups of compounds in this plant, could be the source of production of different bioactive compounds responsible for anti-inflammatory properties. -plant hypertensive.

Patients treated with hibiscus extract showed increased urinary sodium excretion, with no substantial change and no adverse effects or loss of other urinary electrolytes, including potassium. In some studies, hibiscus has been shown to be as effective as the administration of spironolactone-type aldosterone antagonist diuretics used in some instances of hypertension.


Barnes Joan, Anderson A. Linda, Phillipson David J. HerbalMedicines, Pharmaceutical Press, Grande-Bretagne, 2007, troisième édition. Blumenthal M, Goldberg A, Brinckmann J (Ed). Expanded Commission E Monographs, American Botanical Council, publié en collaboration avec IntegrativeMedicine Communications, États-Unis, 2000.

Blumenthal M (Ed). The ABC Clinical Guide to Herbs, American Botanical Council, États-Unis, 2003. Brown D, High Dose Hawthorn Extract for Advanc d Congestive Heart Failure. HerbalGram.2003, numéro 57.American Botanical Council. Natural Products (Professional). Hawt orn. [Consulté le 3 mai 2011].

Ernst Edzard (Ed). The Desktop Guide to Comple entary and Alternative Medicine, Mosby, Grande-Bretagne, 2001.

European Scientific Cooperative on Phytotherapy (Ed.).Crataegi Folium Cum Flore, ESCOP Monographs on the Medicinal Uses of Plants Drugs, Centre for Complementary Health Studies, Universitéd'Exeter, Grande-Bretagne, 1999.

National Library of Medicine (Ed). PubMed, NCBI. [Consulté le 3 mai 2011].

Natural Standard (Ed). Foods, Herbs&Supplements - Hawthorn, Nature Medicine Quality Standard. [Consulté le 3 mai 2011]. Organisation mondiale de la santé. WHO monographs on selected medicinal plants, vol. 2, Suisse, 2002.

Pizzorno JE Jr, Murray Michael T (Ed). Textbook of Natural Medicine, Churchill Livingstone, États-Unis, 1999.

Santé Canada.Médicaments et produits de santé. Base de données d’ingrédients de produits de santé naturels. Monographies à ingrédient unique. [Consulté le 3 mai 2011].

Schulz V, Hänsel R, Tyler VE. Rational Phytotherapy - A Physicians' Guide to Herbal Medicine, fourth edition, Springer, Allemagne, 2001. The Natural Pharmacist (Ed).Natural Products Encyclopedia, Herbs & Supplements - Hawthorn,[Consulté le 3 mai 2011].

Weiss RF, Fintelmann V. Herbal Medicine. Second edition.Thieme, États-Unis, 2000. Hawthorn extract for treating chronic heart failure. Pittler MH, Guo R, Ernst E. Cochrane Database Syst Rev. 2008 Jan 23;(1 :CD005312. Review. The effect of Crataegusoxycantha Special Extract WS 1442 on clinical progression in patients with mild to moderate symptoms of heart failure.Zick SM, Gillespie B, Aaronson KD. Eur J Heart Fail. 2008 Jun;10(6):587-93. Texteintégral :

Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) trial. Zick SM, Vautaw BM, et al. Eur J Heart Fail. 2009 Oct;11(10):990-9. The efficacy and safety of Crataegus extract WS(R) 1442 in patients with heart failure: The SPICE trial. Holubarsch CJ, Colucci WS, et al; on behalf of the Survival and Prognosis: Investigation of Crataegus Extract WS® 1442 in CHF (SPICE) trial study group. Eur J Heart Fail. 2008 Dec;10(12):1255-63. 5. Habs M. Prospective, comparative cohort studies and their contribution to the benefit assessments of therapeutic options: heart failure treatment with and without Hawthorn special extract WS 1442. ForschKomplementarmedKlassNaturheilkd. 2004 Aug;11Suppl 1:36-9.

Tauchert M, Gildor A, Lipinski J. [High-dose Crata gus extract WS 1442 in the treatment of NYHA stage II heart failure] Herz. 1999 Oct;24(6):465-74; discussion 475. German. Erratum in: Herz 1999 Nov;24(7):586.

Schmidt U, Albrecht M, et al. High-dose Crataegus therapy in patients suffering from heart failure NYHA class I and II. Z Phy otherapie 1998;19:22-30. Étude citée et résumée dans : Blumenthal M (Ed). The ABC Clinical Guide to Herbs, American Botanical Council, États-Unis 2003, p. 244.

Loew D, Albrecht M, Podzuweit H. Efficacy and tolerability of a Hawthorn preparation in patients with heart failure stage I an surveillance study. Phytomedicine. 1996;3(Suppl. 1):92. Étudecitée et résuméedans : Blumenthal M (Ed). The ABC Clinical Botanical Council, États-Unis 2003, p. 244.

 II according to NYHA – a guide to Herbs, American Ernst Edzard (Ed). The Desktop Guide to Comple entary and Alternative Medicine, Mosby, Grande-Bretagne, 2001.

Hanack T, Bruckel MH. 1983. The treatment of mild stable forms of angina pectoris using Crategutt novo. Therapiewoche 33:4331–4333. Étude mentionnée et résumée dans : Weiss RF, Fintelmann V. HerbalMedicine. Second edition. Thieme, États-Unis, 2000.

Weng WL, Zhang WQ, et al. Therapeutic effect of Crataeguspinnatifida on 46 cases of angina pectoris--a double blind study. J Tradit Chin

Med 1984;4(4):293-294. Étude citée et résumée dans : Natural Standard (Ed). Foods, Herbs&Supplements - Hawthorn, Nat re MedicineQuality Standard. [Consulté le 3 mai 2011].

Schmidt U, Albrecht M, Schmidt S. Effects of an h rbal crataegus-camphor combination on the symptoms of cardiovascular diseases. Arzneimittelforschung 2000;50(7):613-6 9.

Ventura P, Girola M, Lattuada V. [Clinical evaluation and tolerability of a drug with garlic and hawthorn]. Acta ToxicolTher 1990;11(4):365-372. Étude citée et résumée dans : Natural Standard (Ed). H