What is Titanium?
Titanium is a product
created out of our company's desire to reduce the need for conventional
anti-inflammatory pharmaceutical agents by presenting a natural
anti-inflammatory agent as a viable alternative to synthetic drugs (NSAIDs and
coricoids). For this reason, we are pleased to offer Titanium, a product
focused on quality and meeting the requirements of the Direction de Santé
Naturelle.
Inflammation is a reaction
of the tissues when they perceive no threat. It is an immune defense reaction
of our body to an attack: infection, burn, allergy, etc. Inflammation can be
acute or chronic. Biologically, there is an elevation of haptoglobin,
ceruloplasmin, globulins and ferritin in the context of inflammation.
Titanium is made from 100%
very high-quality natural products that are extremely safe for human
consumption. Titanium can be used as a preventive treatment against acute and
chronic inflammatory diseases and can also be used as a curative product at the
onset of the disease, alone or associated with other anti-inflammatories or
antioxidants.
What is the advantage of
Titanium?
There are two groups of
synthetic products with an inflammatory effect, non-steroidal anti-inflammatory
drugs (NSAIDs) and corticosteroids.
NSAIDs are synthetic
products used mainly in the treatment of joint or bone pain, as antipyretics,
analgesics or antiaggregant. There are qualitative differences in the effects
of different anti-inflammatories, but these differences are not well
identified. However, a person may respond better to one than the other.
NSAID drugs have several
more or less significant side effects: abdominal pain, digestive transit
disorders, ulcerations, perforations, gastric bleeding, etc. They also present
renal effects, rarer than digestive effects but more important such as functional
renal insufficiency. Cutaneous reactions such as urticaria, hematological
reactions such as thrombocytopenia, leukopenia and aplasia. NSAID drugs have
also been identified as having effects on other drugs, including increasing the
free plasma fraction of many drugs, reducing the antihypertensive effects of
b-blockers and the list goes on.
The mode of action of the
second group of synthetic products, corticosteroids, is very complex. Their
effects are perceptible at the level of almost all organs. After entering the
cells, the corticosteroids will bind directly to the DNA. At the level of
genetic heritage, their actions are very diverse, including the reduction of
production of inflammatory and immune factors. In the case of long-term
treatment, side effects systematically appear, for example: aggression towards
the stomach, thinning of the skin, regression of the immune defenses and
abnormal distribution of fat.
The treatment provided by
conventional medication, such as NSAIDs and corticosteroids, targets inflammation
of all kinds, however, the side effects can be very significant and require
careful consideration when choosing treatment.
Titanium uses the synergy
of the components Boswelia and alfa lipoic acid with a spectrum of action that
covers almost all the symptoms induced by inflammatory processes. The clinical
mechanism is not fully understood, but the active ingredients present in these
two components have demonstrated their effectiveness in several clinical
studies. In vitro studies have proven inhibitory activity on the synthesis of
pro-inflammatory enzymes, 5-lipooxygenase (5LO) for Boswelia. Powerful active
antioxidant, both in aqueous and lipid medium, alpha-lipoic acid the second
component, is able to protect all compartments of cells in the body. Many
publications confirm its multiple health benefits and, in particular, the vital
role it plays in the protection of mitochondria.
How to maximize the
therapeutic effect of Titanium?
To be sure that Boswellia
acts effectively, it is recommended to take it, if possible, with a hearty
meal. In a study conducted in 2004, administration of Boswellia extracts
together with the meal led to a substantial improvement in the bioavailability
of Boswellia. This represents an improvement in bioavailability of at least
four times the normal rate (Bone, page 2).
What are the main effects
of taking Titanium?
Titanium being a powerful
anti-inflammatory product, it is recommended in case of inflammation disorders
of all kinds.
It is proven effective
against problems of arthritis, asthma and bronchial asthma, menstrual cramps,
rheumatic diseases, lower back pain and muscle spasms.
For the vast majority of
pathologies, an inflammatory reaction is present, for this reason Titanium is
an essential product.
The combined effects of
the two components of the product make Titanium a product to be used
prophylactically and curatively in all cases of inflammatory reactions. Using
bibliographical sources and clinical observations, we found the perfect synergy
between the two anti-inflammatory and antioxidant components of Titanium.
Boswellia extract was
significantly better than placebo for reducing pain, improving knee flexibility
and increasing walking distance for people with osteoarthritis. Two diseases
have been studied to ensure the benefit of the extract, osteoarthritis and
asthma.
Osteoarthritis
A 2002 study on people
with osteoarthritis of the knee showed that an extract of Boswellia reduced
osteoarthritis symptoms as well as inflammatory blood agents. After a month of
treatment, patients could walk longer distances without pain. After three
months, the researchers saw a reduction in fluid buildup in their joints. In
comparison, patients treated with a placebo showed no improvement. Another
study, lasting two months, came to similar conclusions.
Asthma
A clinical trial compared
80 asthmatics. A group of 40 people took 300 mg of Boswellia extract three
times a day. The second group took a placebo. After 6 weeks, 70% of patients in
the first group reported a marked improvement in their problems compared to 27%
in the placebo group. Again, Boswellia blocks the inflammatory phenomenon.
How to take Titanium
The first pharmacokinetic
study was conducted on humans by Sharma's team in 2004. Digestive absorption of
Boswellia is relatively rapid since the product is reputed to have good gastric
absorption. The plasma peak is observed around 4.5 hours after ingestion, then
the concentration declines steadily.
The plasma half-life is
approximately 6 hours, which requires an oral intake of Titanium approximately
every 6 hours in order to maintain a satisfactory level of active ingredients.
Boswellia is best absorbed when taken with a meal. It is therefore advisable to
take 1 capsule of Titanium one to three times a day with a meal.
The Active Components of Titanium
The revolutionary formula
of Titanium is composed of: Boswellia serrata 70% and alpha lipoic acid (ALA).
We have used both components for their perfect synergy in the treatment of
inflammatory diseases.
Boswellia Serrata
Boswellia serrata has been
added to our complex to contribute to the natural defense of our system.
Research carried out has recently confirmed its therapeutic effectiveness. Its
superiority has been demonstrated by a rigorous battery of tests over non-steroidal
anti-inflammatory drugs (NSAIDs).
An 8-week, double-blind,
placebo-controlled study of 102 people with Crohn's disease compared the effect
of a standardized extract of Boswellia serrata and that of a drug, mesalazine.
According to a standard assessment of Crohn's disease severity, participants
who took the Boswellia extract felt at least as well as those who took the
drug.
Another study with a small
sample size gave some indications that Boswellia extract might also be
beneficial in ulcerative colitis. Studies suggest that it may also provide
beneficial effects in the treatment of arthritis and rheumatoid arthritis and
bronchial asthma. The study of the metabolic stability of boswelic acids
reveals that the extracts of bowelia (Ac) are rapidly metabolized into
hydroxylated derivatives, and they are more hydrophilic than the original
molecule and even more bioavailable than the original molecule.
Alpha Lipoic Acid
ALA particularly targets
cells of diseases such as non-insulin dependent diabetes, neuropathy,
cataracts, liver disorders, neurodegenerative disorders (Alzheimer's,
Parkinson's), atherosclerosis and memory disorders.
Alpha-lipoic acid is a
small molecule that has chemical properties that allow it to easily enter and
exit cells. It directly captures free radicals or removes them from other
antioxidants like vitamins C and E, which has the effect of “recharging” or
“recycling” these.
Alpha-lipoic acid has a
unique chemical structure, both water and fat soluble, it is effective in all
cells of the body. It is the only antioxidant that penetrates brain tissue so
easily. ALA enhances whole-body glucose metabolism and insulin sensitivity in
people with type II diabetes.
Alpha lipoic acid is positively involved in coronary heart disease, hypertension, metabolic syndrome, peripheral neuropathy, alcoholism and shingles, liver disease, metastatic pancreatic cancer, impaired brain function, related problems aging, glaucoma and cataracts.
References
Barrie Cassileth R., Simon Yeung K., Jyothirmai G.; Herb-Drug interactions in oncology, PMPH-USA, 2010, 2e edition, page 104.
Passeport santé, mars 2010, 2e édition, p.104
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http://arthrorganics.com/boswellia.php
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Castleman M., The new healing herbs: the essential guide to more than 125 of nature's most potent herbal remedies, Rodale, 3e edition, 2010, page 116.
Bone K., Boswellia: a new herbal breakthrough for Osteoarthritis, page 2.
http://www.naturalproductsinsider.com/news/2009/03/boswellia-serratas-bioavailability.aspx