What is Sily-M80%?
Sily-M80% is a natural health product that provides liver protection for optimal liver health. The product contains the milk thistle seed extract of the flavonoids (silybin, silydian and silychristin) known as silymarin in 80% concentration.
The name Sily-M80% comes from Silybum marianum, the botanical name for the plant also known as Milk Thistle. This product is used to relieve the affections of the liver and the spleen, calms the pain, it facilitates the intestinal transit by decongesting the gallbladder. It is used to fight gallstones.
Sily-M80% is used for several digestive conditions as well as for liver protection. It protects the liver through its very powerful antioxidant action, allowing the elimination of free radicals. It is the active ingredients of milk thistle, flavonoids (silybin, silydianin and silychristin) known as silymarin (Natural Factors Nutritional Products, 2008) that are used for the therapeutic effects. Sily-M80% is also used in the renewal of liver cells (Lacoste, 2012). It promotes protein synthesis to allow damaged liver cells to be replaced by new liver cells (Natural Factors Nutritional Products, 2008).
What is the advantage of Sily–M80%?
"Nowadays doctors are trying to promote the use of plants for treatments to replace toxic remedies. Using plants over chemical drugs has the advantage of being more natural and all the molecules of the plant act in harmony with the body. The drugs undergo chemical purification and contain a single class of molecules. The plant, instead of having a single and incisive action, reacts slowly and deeply by the synergy of all the substances that it contains." (Scimeca and Tetau, 2005).
Medicines are not without risks, for this reason, we turned to alternative therapy and made use of standardized extracts by formulating Sily-M80%.
How to maximize the therapeutic effect of Sily–M80%?
Administer a mixture of silybin, one of the flavonoids that make up silymarin, and phosphatidylcholine, a type of lipid found in bile and lecithin, to maximize the absorption of silybin (Passeport-Santé, 2011). The active component of Sily–M80%
The Active Component of Sily–M80%
Silibum marianum (Milk Thistle)
The use of standardized 80% silymarin extract was approved in 1989 by Commission E of Germany, as a treatment for liver poisoning as well as as an adjuvant for people with hepatitis or cirrhosis of the liver. In addition, the World Health Organization recognized the same uses in 2002 (Passeport-Santé, 2011).
Germany's Commission E, a committee that includes physicians, pharmacists and herbalists, has approved silymarin extract with a minimum content of 70% to be effective for the treatment of toxic liver damage as well as in adjunctive treatment of chronic inflammatory liver disease and hepatic cirrhosis (Hosein SR and Lyons L, 2002).
In the field of classical medicine, silymarin is used to prevent and treat various liver disorders: cirrhosis, hepatitis, gallstones, jaundice (jaundice) as well as damage caused by toxic substances. Clinicians believe that silymarin helps regenerate damaged liver tissue and protects it against the effects of natural or synthetic toxins (Passeport-Santé, 2011).
A study done on workers who had been exposed to hepatotoxic industrial solvents found milk thistle to have detoxifying potential. After a 30-day treatment, the workers were able to observe a significant improvement in their liver function parameters as well as in their platelets (Szilard and Szentgyorgyi, 1988).
Milk Thistle According to the monographs of the European Scientific Cooperative for Phytotherapy (ESCOP) 2009, in vitro tests would have made it possible to find several properties of Milk Thistle. This plant would stabilize cell membranes, improve cholestasis, has an antifibrotic, anti-inflammatory and antioxidant effect.
In addition, the structure of flavonoids is similar to cortisone, which generates DNA-dependent RNA polymerase transcription in the cell nucleus of isolated liver and kidney cells. This helps regenerate liver function and increases protein synthesis (Chrubasik, 2013).
According to a clinical study carried out on 56 patients with type 2 diabetes, the use of standardized extract of Milk Thistle at the rate of 200 mg, 3 times a day for a period of 3 months, would help to better control blood sugar. There would also be a decrease in cholesterol and triglyceride levels in the blood (Huseini, et al. 2006)
A team of researchers from the University of California demonstrated various modes of action of silybin with hepatoprotective properties. This study was published in the World Journal of Gastroenterology.
A third study was carried out on 170 patients with cirrhosis of the liver, 91 of these patients were suffering from alcoholism. The treatment was a dose of 140 mg of silymarin 3 times a day for a period of four months. The results obtained were a survival rate of 58% for a period of 4 years for the patients having obtained the silymarin supplementation and a rate of only 39% for the same number of years for the group having obtained the placebo (Ferenci P. et al.1989).
According to clinical experiments carried out, there has been confirmation of the effect of milk thistle for the elimination of the symptoms of several liver conditions, acute and chronic, ranging from viral hepatitis to cirrhosis (Mowrey, 1990).
Researchers from the American University of Columbia carried out a clinical trial showing that the use of Milk Thistle makes it possible to limit liver toxicity for patients undergoing chemotherapy treatments and reduces the risk of therapeutic abandonment. The active molecule of milk thistle, silymarin, was isolated in order to measure its effectiveness. Patients took milk thistle, the extract standardized to 80 mg of silymarin, and others a placebo, during their chemotherapy treatment. It was observed that 72% of patients taking the placebo had to reduce the doses of chemotherapy against 61% who took milk thistle extracts (Ladas et al. 2009).
A recent in vitro study demonstrated the ability of silybin to arrest cell progression in these prostate cancer cell lines, possibly by inhibiting many protein kinases. In this study, the researchers observed that silybin transformed a large proportion of cells that were malignant into normal prostate cells that differentiated (Pro Natl Acad Sci USA, 1999).
Chrubasik, Sigrun (2013) Les troubles hépatique résultent des causes les plus diverses : L'extrait de chardon- Marie peut s'utiliser dans de multiples affections.
Dr. Ron. Dr. Ron's Ultra-Pure: the additive-free company. 2012
Ferenci P. et al., Randomized, controlled trial of silymarin treatment in patients with cirrhosis of the liver, J. Hepatol., 1989, 9:105-13
Gebhardt R. Antioxydative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxyde-induced oxidative stress in cultured rat hepatocytes. Toxicol Appl Pharmacol 1997;144:279-86. Hosein SR, Lyons L (2002) Le chardon-marie.
http://www.catie.ca/fr/feuillets-info/vitamines-supplements/chardon-marie. Consulté le 3 mai 2013.
J Hepatol, 1989 ; 8 : 105-13 La source canadienne de renseignements sur le VIH et l'hépatite C (2013) Chardon-Marie
Lacoste, Sophie (2012) Ma bible des trucs de sa té: La bible de tous les trucs qui marchent pour se soigner ! Leduc.s éditi ns. Paris. 456p.
Ladas et al. A randomized, controlled, double-bli d, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer, 2009
Les traitements (2011) Les traitements : Psoriasi le 3 mai 2013.
Mowrey, Daniel B., "Next Generation Herbal Medecine : guaranteed potencyheros," Keats Publishing, 1990. Oronalia (201 ) Silymarine 300 mg.
http://www.oronalia.com/fichier/silymarine202.pdf?PHPSESSID=dd0f7b38d834bda232d89ffa1498eeb2. Consulté le 7 mai 20 3.
Passeport-Santé (2011) Chardon-Marie
Natural Factors Nutritional Products (2008) Extrait De Chardon-Marie : Pourquoi fait-on un si grand cas de ce caroténoïde?
Pierre, Michel, Lys, Michel (2007) Secrets des pl
Proc Natl Acad Sci USA 1999 ; 96 :7490S
Santé Canada (2009) Médicaments et produits de santé : Chardon-Marie.
http://www.hc-sc.gc.ca/dhp-mps/prodnatur/applications/licen-prod/monograph/archive_mono_thistle-chardon-fra.php. Consulté le 30 avril 2013.
Scimeca, Daniel, Tétau, Max (2005) Votre santé par les plantes: Le guide phyto utile pour toute la famille: C'est naturel, c'est ma santé. Alpen Editions s.a.m. Paris. 135p.
Szilard S, Szentgyorgyi D, Demeter I. Protective effect of Legalon in workers exposed to organic solvents. Acta Med Hung 988; 45(2):249-56
The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Huseini HF, Larijani B, et al. Phytother Res 2 06;20;1036-9.
World Journal of Gastroenterology, 2007 (13,40), p.5299-5305.